The Antioxidant and Tyrosinase-inhibiting Activities of 8-O-4′ Neolignans from Crataegus pinnatifida Seeds
نویسندگان
چکیده
Many tyrosinase inhibitors have been alleged to have serious side effects. To search for relatively mild and safe tyrosinase inhibitors, two new 8-O-4′ neolignans, named huangnin A (1) and B (2), and four known analogs (3-6) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses (1D, 2D NMR, HRESIMS, CD and Rh2(OCOCF3)4-induced CD). In addition, the in vitro antioxidant and anti-tyrosinase activities of all isolates were evaluated. The results showed that compound 5 has good antioxidant and promising tyrosinase-inhibiting activities.
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